First published in 1920, "Main Street" is a biting and satirical look at small town America. Set in the 1910s it follows the struggles of its heroine, Carol Milford, to adapt to small town life. Carol, a young and progressive librarian living in St Paul, Minnesota, falls in love with and marries Will Kennicott, a doctor who dreams of returning to the small town of his childhood. Carol agrees and they move to Gopher Prairie, Minnesota, a town modeled...

After years of work as a small town doctor and a research scientist, Arrowsmith heads for the West Indies with a serum to halt an epidemic. A tragic turn of events forces him to come to terms with his career and his personal life.